No significant side effects reported.
As Melatonin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Melatonin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Melatonin could have any negative effects on these vulnerable groups. It should be safe to use Melatonin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Melatonin for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Melatonin is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Melatonin reported up to now.
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1. Melatonin is formed during winemaking at safe levels of biogenic amines.[Food Chem Toxicol. 2013 Jul]
Author: Rodriguez-Naranjo MI, Ordóñez JL, Callejón RM, Cantos-Villar E, Garcia-Parrilla MC.
2. The use of high-dose melatonin in liver resection is safe: first clinical experience.[J Pineal Res. 2011 May]
Author: Nickkholgh A, Schneider H, Sobirey M, Venetz WP, Hinz U, Pelzl le H, Gotthardt DN, Cekauskas A, Manikas M, Mikalauskas S, Mikalauskene L, Bruns H, Zorn M, Weigand MA, Büchler MW, Schemmer P.
3. Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis.[J Pineal Res. 2006 Sep]
Author: Pignone AM, Rosso AD, Fiori G, Matucci-Cerinic M, Becucci A, Tempestini A, Livi R, Generini S, Gramigna L, Benvenuti C, Carossino AM, Conforti ML, Perfetto F.
4. Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug?[J Pineal Res. 2003 Aug]
Author: Shiu SY, Reiter RJ, Tan DX, Pang SF.