Diosmin, CAS# 520-27-4, is a Plant extracts manufactured through plant extraction, available as Greyish-yellow or light yellow hygroscopic powder. Diosmin is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
As Diosmin is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Diosmin for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Diosmin could have any negative effects on these vulnerable groups. It should be safe to use Diosmin in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Diosmin for long period in food for newborns or pregnant.
Though Diosmin is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Diosmin reported up to now.
1. Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports.[J Med Case Rep. 2014 Jun 16]
Author: Milano G, Leone S, Fucile C, Zuccoli ML, Stimamiglio A, Martelli A, Mattioli F.
2. [Semisynthetic Diosmin (Phlebodia 600) for therapy of lower limb chronic venous insufficiency].[Angiol Sosud Khir. 2006]
Author: Kirienko AI, Bogachev VIu, Zolotukhin IA, Golovanova OV.
