甲萘醌(维生素K3), CAS# 58-27-5, is a fat-soluble vitamin manufactured through chemical synthesis, available as Yellowish crystalline powder. Menadione is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
No significant side effects reported.
As Menadione is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Menadione for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Menadione could have any negative effects on these vulnerable groups. It should be safe to use Menadione in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Menadione for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Menadione is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about Menadione reported up to now.
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1. Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells.[Leuk Res. 2014 Jul]
Author: Baran I, Ionescu D, Filippi A, Mocanu MM, Iftime A, Babes R, Tofolean IT, Irimia R, Goicea A, Popescu V, Dimancea A, Neagu A, Ganea C.
2. Apoptosis provoked by the oxidative stress inducer menadione (Vitamin K(3)) is mediated by the Fas/Fas ligand system.[Clin Immunol. 1999 Oct]
Author: Caricchio R, Kovalenko D, Kaufmann WK, Cohen PL.