L-Valine, CAS# 72-18-4, is a proteinogenic amino acid manufactured through chemical synthesis, available as white powder. L-Valine is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
Prolonged, excessive consumption might cause hallucinations.
As L-Valine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Valine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Valine could have any negative effects on these vulnerable groups. It should be safe to use L-Valine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Valine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Valine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Valine reported up to now.
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1. Application of metabolic engineering for the biotechnological production of L-valine.[Appl Microbiol Biotechnol. 2014 Jul]
Author: Oldiges M, Eikmanns BJ, Blombach B.
2. Conformation of dehydropentapeptides containing four achiral amino acid residues - controlling the role of L-valine.[Beilstein J Org Chem. 2014 Mar 14]
Author: Jewgiński M, Krzciuk-Gula J, Makowski M, Latajka R, Kafarski P.
3. Ruthenium-nitrosyl complexes with glycine, L-alanine, L-valine, L-proline, D-proline, L-serine, L-threonine, and L-tyrosine: synthesis, X-ray diffraction structures, spectroscopic and electrochemical properties, and antiproliferative activity.[Inorg Chem. 2014 Mar 3]
Author: Rathgeb A, Böhm A, Novak MS, Gavriluta A, Dömötör O, Tommasino JB, Enyedy EA, Shova S, Meier S, Jakupec MA, Luneau D, Arion VB.
4. Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.[PLoS One. 2014 Jan 17]
Author: Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J.
