L-Isoleucine, CAS# 73-32-5, is a hydrophobic amino acid manufactured through chemical synthesis, available as White crystals or crystalline Powder. L-Isoleucine is widely used as nutritional supplements. It is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries.
Over consumption may lead to liver disease, excesive urination, and depression.
As L-Isoleucine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Isoleucine for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Isoleucine could have any negative effects on these vulnerable groups. It should be safe to use L-Isoleucine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Isoleucine for long period in food for newborns or pregnant.
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Isoleucine is considered safe by FDA according to existing data and granted GRAS status.
No breaking news or public health crises reported about L-Isoleucine reported up to now.
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1. Local rhamnosoft, ceramides and L-isoleucine in atopic eczema: a randomized, placebo controlled trial.[Pediatr Allergy Immunol. 2014 May]
Author: Marseglia A, Licari A, Agostinis F, Barcella A, Bonamonte D, Puviani M, Milani M, Marseglia G.
2. Reductive amination by recombinant Escherichia coli: whole cell biotransformation of 2-keto-3-methylvalerate to L-isoleucine.[J Biotechnol. 2013 Nov]
Author: Lorenz E, Klatte S, Wendisch VF.
3. L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes.[Food Chem Toxicol. 2013 Sep]
Author: Xie XL, Kakehashi A, Wei M, Yamano S, Takeshita M, Yunoki T, Wanibuchi H.
4. Rational design of Escherichia coli for L-isoleucine production.[ACS Synth Biol. 2012 Nov 16]
Author: Park JH, Oh JE, Lee KH, Kim JY, Lee SY.
